Collagen + Vitamin C 90 caps.

• THE PERFECT CHOICE IF YOU ARE LOOKING FOR A COMBINATION OF COLLAGEN AND VITAMIN C
• EACH PORTION IS UP TO 1000 MG OF COLLAGEN
• COLLAGEN IS AN ESSENTIAL CELL COMPONENT IN THE CONNECTIVE TISSUE
• COLLAGEN HYDROLYZATE IS Categorized as BIOACTIVE PEPTIDES
• BECAUSE OF ITS LOW MOLECULAR WEIGHT, HYDROLYZED COLLAGEN IS EASILY DIGESTED, ABSORBED AND DISTRIBUTED IN THE HUMAN BODY
• VITAMIN C HELPS IN THE PROPER PRODUCTION OF COLLAGEN *

Essence Collagen + Vitamin C is a dietary supplement in the form of capsules containing collagen hydrolyzate and vitamin C.

What role does collagen play in our body?

Collagen makes up about 30% of the body's protein mass and plays an essential role in the structure of various types of tissues, giving stiffness and integrity to bones and skin. Collagen fibre has a triple spiral structure. Type I collagen occurs in mammals. The skin contains type I and III collagen, and cartilage contains type II and III collagen. Collagen fibres give these tissues tensile strength. The extracellular matrix consists mainly of collagen proteoglycans. Resistance, molecular filtration, and skin hydration are determined by proteoglycans, which also influence cell behaviour or cell-to-cell interactions (1). It can be said that fibroblasts (that is, the connective tissue cells that exist in the dermis) are entirely dependent on vitamin C for collagen synthesis and the regulation of the collagen/elastin balance in the dermis (2).

What is Hydrolyzed Collagen?

Hydrolysed collagen consists of small, low molecular weight peptides. It is because of this low molecular weight that hydrolyzed collagen is easily digested, absorbed and distributed throughout the human body. Collagen peptides are used as critical active ingredients due to their different bioactivity, high bioavailability and good biocompatibility (5). Collagen hydrolyzate is classified as a bioactive peptide. It is rich in amino acids like glycine and proline, and when digested, it builds up in the cartilage or skin and helps to maintain stability or regeneration (1).

Vitamin C is essential for the formation of collagen fibres and cell differentiation

* Vitamin C helps in the proper production of collagen to ensure the proper functioning of not only bones, cartilage and skin, but also blood vessels, gums and teeth. The idea is that vitamin C plays an essential role in connective tissue functions by being a cofactor of enzymes that catalyze the hydroxylation of procollagen proline and lysine residues, promoting the correct folding of the stable collagen structure. In addition to its role in collagen synthesis, vitamin C acts as a powerful antioxidant by neutralizing harmful reactive oxygen species. That is, vitamin C helps to protect cells against oxidative stress. All this is confirmed by numerous studies which have shown that vitamin C can increase the synthesis of type I collagen and reduce the parameters of oxidative stress (3, 4).

Collagen and physical activity

Various studies have suggested that collagen-based tissues (i.e. ligaments, tendons, cartilage) are more dynamic than previously thought, with similar rotation rates to skeletal muscle tissue. Connective tissue adaptations, including increased stiffness due to higher collagen content and cross-linking, reduce the risk of injury because tendon stiffness is linearly related to resistance to damage. It is known that intense exercise increases collagen synthesis as well as the expression of the main enzyme involved in collagen cross-linking. The result is a training-induced increase in connective tissue density and stiffness. Collagen hydrolyzate used before exercise may increase the delivery of key amino acids (e.g., glycine, proline, hydroxyproline) to the connective tissue. However, it should be remembered that in order to have a measurable effect on the mechanical function of connective tissues, the ingested amino acids must be digested, absorbed, transported to the target tissue, and then integrated with the collagen protein (6).

Literature:

Lupu M. A., Gradisteanu Pircalabioru G., Chifiriuc M. C., Albulescu R., Tanase C., Beneficial effects of food supplements based on hydrolyzed collagen for skin care (Review). Experimental and Therapeutic Medicine, 2020, 20 (1), 12-17.

Pullar J. M., Carr A. C., Vissers M., The Roles of Vitamin C in Skin Health. Nutrients, 2017, 9 (8), 866.

Commission Regulation (EU) No 432/2012 of 16 May 2012 established a list of permitted health claims made on foods, other than those referring to the reduction of disease risk and to children's development and health.

DePhillipo N. N., Aman Z. S., Kennedy M. I., Begley J. P., Moatshe G., LaPrade R. F., Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthopedic Journal of Sports Medicine, 2018, 6 (10), 2325967118804544.

Bianchi F. M., Angelinetta C., Rizzi G., Praticò A., Villa R., Evaluation of the Efficacy of a Hydrolyzed Collagen Supplement for Improving Skin Moisturization, Smoothness, and Wrinkles. The Journal of Clinical and Aesthetic Dermatology, 15 (3), 48-52.

Lis D. M., Jordan M., Lipuma T., Smith T., Schaal K., Baar K., Collagen and Vitamin C Supplementation Increases Lower Limb Rate of Force Development. International Journal of Sport Nutrtion Exercise Metabolism, 2022 Mar 1; 32 (2): 65-73.