Inosine Plus for immunne system 90 caps.
Essence Inosine Plus is a dietary supplement in the form of capsules containing inositol, CLA, zinc, L-lysine hydrochloride, L-histidine and grapefruit extract
- COMPLEX FORMULA THAT IS BASED ON INOSINE
- THE COMPOSITION ALSO INCLUDES CLA, ZINC, AMINO ACIDS AND GRAPEFRUITS EXTRACT
- INOSINE DISPLAYS IMMUNOMODULATING PROPERTIES (1)
- ZINC HELPS IN THE PROPER FUNCTIONING OF THE IMMUNE SYSTEM
- ZINC SUPPORTS THE PROTECTION OF CELLS AGAINST OXIDATIVE STRESS
- GRAPEFRUIT SUPPORTS THE IMMUNITY OF THE ORGANISM AND SUPPORTS THE DEFENSIVE SYSTEM
Essence Inosine Plus is a dietary supplement in the form of capsules containing inositol, CLA, zinc, L-lysine hydrochloride, L-histidine and grapefruit extract (Citrus paradisi) standardized for the content of naringenin.
Inosine - what is it?
If you are wondering what this mysterious compound is, you need to know that inosine is an endogenous purine nucleoside formed by the deamination (that is, the elimination of the amino group) of adenosine. Like adenosine, it is produced and released into the extracellular space during normal cellular metabolism. Adenosine has a short half-life (approximately 10 seconds) and is rapidly converted to inosine, a stable metabolite with a half-life of roughly 15 hours. Similar to adenosine, inosine, acting through adenosine receptors, exhibit a broad spectrum of immunomodulatory properties, i.e. it may affect the immune system (1).
What is CLA?
Conjugated linoleic acid (CLA) is a mixture of fatty acids, positional geometric isomers of linoleic acid with a conjugated system of double bonds (2). Conjugated linoleic acid belongs to the group of polyunsaturated fatty acids, which have a significant influence on the proportions of the composition of the immune cell membrane. Some of the immunomodulatory properties of CLA are similar to those of polyunsaturated fatty acids. Since CLA is an analogue of linoleic acid, it is incorporated into membrane phospholipids, thus influencing the fluidity of the membrane and the function of the transmembrane receptor in immune cells (3).
Important amino acids, i.e. L-histidine and L-lysine
L-histidine is an essential amino acid (EAA) with unique biochemical and physiological properties. Necessary, because the human body is unable to produce it, therefore it must be supplied with the diet. L-histidine is an amino acid with a unique role, among others. in proton buffering, metal ion chelation, scavenging reactive oxygen and nitrogen species (4). Lysine is also an essential amino acid that must be consumed in adequate amounts to maintain protein synthesis. Already in the 1950s, it was shown that lysine is necessary for the diet of people to create a positive nitrogen balance (5).
Zinc is a micronutrient of great importance for immunity
Zinc is a trace element that is essential for a huge number of organ systems. Virtually every aspect of human biology has to do with zinc in some way. It has been known for years that zinc is an important factor for the immune system (6). It affects many aspects of it, from the skin barrier to the regulation of genes in lymphocytes. Zinc is essential for the proper development and functioning of cells mediating non-specific (i.e. innate) immunity and contributes to the development of acquired immunity. Zinc also acts as an antioxidant and can stabilize cell membranes (7). The important thing to remember about zinc is that it helps in the proper functioning of the immune system and protects cells from oxidative stress. Additionally, it supports the proper synthesis of DNA and protein (8).
Grapefruit for immunity?
Yes! In Inosine Plus you will find a grapefruit extract standardized for the content of naringenin. As for the grapefruit itself, it has been shown to support the body's immunity and support defence system (9). Naringenin belongs to the group of flavonoids and is manifested, among others, by the antioxidant effect (10).
Welihinda A. A., Kaur M., Greene K., Zhai Y., Amento E.P., The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signalling bias. Cell Signal. 2016 Jun; 28 (6): 552-60.
Cho K., Song Y., Kwon D., Conjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type 4 protein expression in the skeletal muscles of rats during endurance exercise. Iranian Journal Basic Medical Sciences, 2016 Jan; 19 (1): 20-7. PMID: 27096060; PMCID: PMC4823612.
Xi He, Haijun Zhang, Xiaojun Yang, Shirui Zhang, Qiuzhong Dai, Wenjun Xiao & Guopu Ren, Modulation of immune function by conjugated linoleic acid in chickens, Food and Agricultural Immunology, 2007, 18: 3-4, 169-178.
Holeček M. Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement. Nutrients, 2020, Mar 22; 12 (3): 848.
Matthews D. E., Review of Lysine Metabolism with a Focus on Humans. Journal of Nutrition, 2020 Oct 1; 150 (Suppl 1): 2548S-2555S.
Haase H., Rink L., Multiple impacts of zinc on immune function. Metallomics, 2014, Jul; 6 (7): 1175-80.
Shankar A. H., Prasad A. S., Zinc and immune function: the biological basis of altered resistance to infection. The American Journal of Clinical Nutrition, 1998, Aug; 68 (2 Suppl): 447S-463S.
Commission Regulation (EU) No 432/2012 of 16 May 2012 established a list of permitted health claims made on foods, other than those referring to the reduction of disease risk and to children's development and health.
A PENDING list published on the basis of Commission Regulation (EU) No. 432/2012 of 16 May 2012 establishing a list of permitted health claims made on foods, other than those relating to the reduction of disease risk and to children's development and health.
Alam M.A., Subhan N., Rahman M. M., Uddin S. J., Reza H. M., Sarker S. D., Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Advances in Nutrition, 2014 Jul 14; 5 (4): 404-17.
Inosine Plus for immunne system 90 caps.
|Ilość porcji w opakowaniu:||45|
|Mass net:||69.30 g|
|Wartość odżywcza / Informacja żywieniowa|
|na 2 kaps.||% RWS*|
|Sprzężony kwas linolowy||240 mg||-|
|w tym CLA||192 mg||-|
|Chlorowodorek L-lizyny||200 mg||-|
|w tym L-lizyna||160 mg||-|
|Ekstrakt grapefruita||4 mg||-|
|w tym naryngenina||3.92 mg||-|